1980 - The biological functions of NO (Nitric Oxide) were discovered and caused quite a stir.

1992 - NO was named molecule of the year by the journal Science. Later a scientific journal devoted entirely to NO was created.

1998 - The Nobel Prize for Medicine was awarded to three men for the discovery of the signaling properties of NO.

It is estimated that 3,000 journal articles about the biological roles of NO have been published.

  • Ignarro, Louis J., No More Heart Disease. St. Martins Press. New York. 2005
  • BIVALACQUA, USTA, CHAMPION, et al. Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease Journal of Andrology, Vol. 24, No. 6 Supplement, November/December 2003
  • Noel N. Kim,* David W. Christianson,** and Abdulmaged M. Traish*†3Role of Arginase in the Male and Female Sexual Arousal Response1,2 Journal of Clinical Nutrition, 2004
  • “Oral L-Citrulline supplementation raises plasma L-Arginine concentration and augments NO-dependent signaling in a dose dependent manner.” Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-Citrulline and L-Arginine: impact on nitric oxide metabolism. British Journal of Clinical Pharmacology. 2007.
  • “Arginine is converted in endothelial cells to NO and Citrulline. Oral L-Arginine reduced systolic BP from 135+/- 7 to 123+/-8 mmHg which is a 10 point drop. And an average of 10 pts diastolic.” Huynh N., Tayek J., Oral Arginine reduces systemic Blood Pressure in Type 2 Diabetes: Its Potential Role in Nitric Oxide generation. The Journal of the American College of Nutrition. 2002.
  • M Hecker, W C Sessa, H J Harris, E E Anggård, and J R Vane. The metabolism of L-Arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-Citrulline to L-Arginine

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